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DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation
Actively transcribed genes in mammals are decorated by H3K79 methylation, which is correlated with transcription levels and is catalyzed by the histone methyltransferase DOT1L. DOT1L is required for mammalian development, and the inhibition of its catalytic activity has been extensively studied for...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7959542/ https://ncbi.nlm.nih.gov/pubmed/33077595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001075117 |
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