DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation

Actively transcribed genes in mammals are decorated by H3K79 methylation, which is correlated with transcription levels and is catalyzed by the histone methyltransferase DOT1L. DOT1L is required for mammalian development, and the inhibition of its catalytic activity has been extensively studied for...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Cao, Kaixiang, Ugarenko, Michal, Ozark, Patrick A., Wang, Juan, Marshall, Stacy A., Rendleman, Emily J., Liang, Kaiwei, Wang, Lu, Zou, Lihua, Smith, Edwin R., Yue, Feng, Shilatifard, Ali
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959542/
https://ncbi.nlm.nih.gov/pubmed/33077595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001075117
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