DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation

Actively transcribed genes in mammals are decorated by H3K79 methylation, which is correlated with transcription levels and is catalyzed by the histone methyltransferase DOT1L. DOT1L is required for mammalian development, and the inhibition of its catalytic activity has been extensively studied for...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Proc Natl Acad Sci U S A
المؤلفون الرئيسيون: Cao, Kaixiang, Ugarenko, Michal, Ozark, Patrick A., Wang, Juan, Marshall, Stacy A., Rendleman, Emily J., Liang, Kaiwei, Wang, Lu, Zou, Lihua, Smith, Edwin R., Yue, Feng, Shilatifard, Ali
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2020
الموضوعات:
Biological Sciences
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959542/
https://ncbi.nlm.nih.gov/pubmed/33077595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001075117
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