Targeting Processive Transcription Elongation Via SEC Disruption for Myc Induced Cancer Therapy

The Super Elongation Complex (SEC) is required for robust and productive transcription through release of RNA Polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC contributes to multiple human diseases including cancer. He...

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Gepubliceerd in:Cell
Hoofdauteurs: Liang, Kaiwei, Smith, Edwin R., Aoi, Yuki, Stoltz, Kristen L., Katagi, Hiroaki, Woodfin, Ashley R., Rendleman, Emily J., Marshall, Stacy A., Murray, David C., Wang, Lu, Ozark, Patrick A., Mishra, Rama K., Hashizume, Rintaro, Schiltz, Gary E., Shilatifard, Ali
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422358/
https://ncbi.nlm.nih.gov/pubmed/30340042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.09.027
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