Excess growth hormone suppresses DNA damage repair in epithelial cells

Growth hormone (GH) decreases with age, and GH therapy has been advocated by some to sustain lean muscle mass and vigor in aging patients and advocated by athletes to enhance performance. Environmental insults and aging lead to DNA damage, which — if unrepaired — results in chromosomal instability a...

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Foilsithe in:JCI Insight
Main Authors: Chesnokova, Vera, Zonis, Svetlana, Barrett, Robert, Kameda, Hiraku, Wawrowsky, Kolja, Ben-Shlomo, Anat, Yamamoto, Masaaki, Gleeson, John, Bresee, Catherine, Gorbunova, Vera, Melmed, Shlomo
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2019
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413789/
https://ncbi.nlm.nih.gov/pubmed/30728323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125762
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