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Growth Hormone Induces Colon DNA Damage Independent of IGF-1

DNA damage occurs as a result of environmental insults and aging and, if unrepaired, may lead to chromosomal instability and tumorigenesis. Because GH suppresses ataxia-telangiectasia mutated kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether G...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Chesnokova, Vera, Zonis, Svetlana, Barrett, Robert J, Gleeson, John P, Melmed, Shlomo
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530523/
https://ncbi.nlm.nih.gov/pubmed/31002310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00132
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