DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas

Drivers of sporadic benign pituitary adenoma growth are largely unknown. Whole-exome sequencing of 159 prospectively resected pituitary adenomas showed that somatic copy number alteration (SCNA) rather than mutation is a hallmark of hormone-secreting adenomas and that SCNAs correlate with adenoma ph...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ben-Shlomo, Anat, Deng, Nan, Ding, Evelyn, Yamamoto, Masaaki, Mamelak, Adam, Chesnokova, Vera, Labadzhyan, Artak, Melmed, Shlomo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598090/
https://ncbi.nlm.nih.gov/pubmed/32673291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138540
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