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STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion
Pituitary somatotroph adenomas result in dysregulated growth hormone (GH) hypersecretion and acromegaly; however, regulatory mechanisms that promote GH hypersecretion remain elusive. Here, we provide evidence that STAT3 directly induces somatotroph tumor cell GH. Evaluation of pituitary tumors revea...
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| Publicado no: | J Clin Invest |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4396466/ https://ncbi.nlm.nih.gov/pubmed/25774503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78173 |
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