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Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation And Hormone Secretion

Pyridoxal phosphate (PLP), a bio-active form of pyridoxine, (10-1000 μM) dose-dependently inhibited cell proliferation in rat pituitary MMQ and GH3 cells, and in mouse AtT-20 cells. After 4 days, MMQ cell numbers were reduced by up to 81%, GH3 cell numbers were reduced by up to 64% (p<0.05) and A...

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Autores principales: Ren, Song-Guang, Melmed, Shlomo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1513048/
https://ncbi.nlm.nih.gov/pubmed/16690808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2005-1219
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