Growth hormone is permissive for neoplastic colon growth

Growth hormone (GH) excess in acromegaly is associated with increased precancerous colon polyps and soft tissue adenomas, whereas short-stature humans harboring an inactivating GH receptor mutation do not develop cancer. We show that locally expressed colon GH is abundant in conditions predisposing...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Chesnokova, Vera, Zonis, Svetlana, Zhou, Cuiqi, Recouvreux, Maria Victoria, Ben-Shlomo, Anat, Araki, Takako, Barrett, Robert, Workman, Michael, Wawrowsky, Kolja, Ljubimov, Vladimir A., Uhart, Magdalena, Melmed, Shlomo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988562/
https://ncbi.nlm.nih.gov/pubmed/27226307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600561113
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