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p21(Cip1) restrains pituitary tumor growth

As commonly encountered, pituitary adenomas are invariably benign. We therefore studied protective pituitary proliferative mechanisms. Pituitary tumor transforming gene (Pttg) deletion results in pituitary p21 induction and abrogates tumor development in Rb(+/−)Pttg(−/−) mice. p21 disruption restore...

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Detalhes bibliográficos
Main Authors: Chesnokova, Vera, Zonis, Svetlana, Kovacs, Kalman, Ben-Shlomo, Anat, Wawrowsky, Kolja, Bannykh, Serguei, Melmed, Shlomo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577704/
https://ncbi.nlm.nih.gov/pubmed/18981426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804810105
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