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p21(Cip1) restrains pituitary tumor growth
As commonly encountered, pituitary adenomas are invariably benign. We therefore studied protective pituitary proliferative mechanisms. Pituitary tumor transforming gene (Pttg) deletion results in pituitary p21 induction and abrogates tumor development in Rb(+/−)Pttg(−/−) mice. p21 disruption restore...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577704/ https://ncbi.nlm.nih.gov/pubmed/18981426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804810105 |
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