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p21(Cip1) restrains pituitary tumor growth
As commonly encountered, pituitary adenomas are invariably benign. We therefore studied protective pituitary proliferative mechanisms. Pituitary tumor transforming gene (Pttg) deletion results in pituitary p21 induction and abrogates tumor development in Rb(+/−)Pttg(−/−) mice. p21 disruption restore...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577704/ https://ncbi.nlm.nih.gov/pubmed/18981426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804810105 |
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