MON-475 Growth Hormone Induces Colon Tissue DNA Damage Independently of IGF-1

Environmental insults and aging lead to DNA damage, which, if unrepaired, results in chromosomal instability and tumorigenesis. We have shown that GH suppresses phosphorylation of ATM and its target proteins p53, Chk2, and H2AX in DNA damaged non-tumorous human colon cells. We show that GH decreased...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Endocr Soc
Egile Nagusiak: Chesnokova, Vera, Zonis, Svetlana, Barrett, Robert, Gleeson, John, Gorbunova, Vera, Melmed, Shlomo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Endocrine Society 2019
Gaiak:
Neuroendocrinology and Pituitary
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550948/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-475
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