MON-475 Growth Hormone Induces Colon Tissue DNA Damage Independently of IGF-1

Environmental insults and aging lead to DNA damage, which, if unrepaired, results in chromosomal instability and tumorigenesis. We have shown that GH suppresses phosphorylation of ATM and its target proteins p53, Chk2, and H2AX in DNA damaged non-tumorous human colon cells. We show that GH decreased...

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Bibliografiska uppgifter
I publikationen:J Endocr Soc
Huvudupphovsmän: Chesnokova, Vera, Zonis, Svetlana, Barrett, Robert, Gleeson, John, Gorbunova, Vera, Melmed, Shlomo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Endocrine Society 2019
Ämnen:
Neuroendocrinology and Pituitary
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550948/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-475
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