MON-475 Growth Hormone Induces Colon Tissue DNA Damage Independently of IGF-1

Environmental insults and aging lead to DNA damage, which, if unrepaired, results in chromosomal instability and tumorigenesis. We have shown that GH suppresses phosphorylation of ATM and its target proteins p53, Chk2, and H2AX in DNA damaged non-tumorous human colon cells. We show that GH decreased...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Endocr Soc
Hlavní autoři: Chesnokova, Vera, Zonis, Svetlana, Barrett, Robert, Gleeson, John, Gorbunova, Vera, Melmed, Shlomo
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2019
Témata:
Neuroendocrinology and Pituitary
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550948/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-475
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky