MON-475 Growth Hormone Induces Colon Tissue DNA Damage Independently of IGF-1

Environmental insults and aging lead to DNA damage, which, if unrepaired, results in chromosomal instability and tumorigenesis. We have shown that GH suppresses phosphorylation of ATM and its target proteins p53, Chk2, and H2AX in DNA damaged non-tumorous human colon cells. We show that GH decreased...

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Bibliografische gegevens
Gepubliceerd in:J Endocr Soc
Hoofdauteurs: Chesnokova, Vera, Zonis, Svetlana, Barrett, Robert, Gleeson, John, Gorbunova, Vera, Melmed, Shlomo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Endocrine Society 2019
Onderwerpen:
Neuroendocrinology and Pituitary
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550948/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-475
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