The chromatin accessibility landscape of primary human cancers

We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from The Cancer Genome Atlas. We identify 562,709 transposase-accessible DNA elements that substantially extend the compendium of known cis-regulatory elements. Integration of ATAC-seq with TCGA...

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Publicado en:Science
Autores principales: Corces, M. Ryan, Granja, Jeffrey M., Shams, Shadi, Louie, Bryan H., Seoane, Jose A., Zhou, Wanding, Silva, Tiago C., Groeneveld, Clarice, Wong, Christopher K., Cho, Seung Woo, Satpathy, Ansuman T., Mumbach, Maxwell R., Hoadley, Katherine A., Robertson, A. Gordon, Sheffield, Nathan C., Felau, Ina, Castro, Mauro A.A., Berman, Benjamin P., Staudt, Louis M., Zenklusen, Jean C., Laird, Peter W., Curtis, Christina, Greenleaf, William J., Chang, Howard Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408149/
https://ncbi.nlm.nih.gov/pubmed/30361341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav1898
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