Transcript-indexed ATAC-seq for precision immune profiling

T cells create vast amounts of diversity in their T cell receptor (TCR) genes, enabling individual clones to recognize specific peptide-MHC ligands. Here we combine TCR sequencing and assay for transposase-accessible chromatin analysis at the single-cell level to provide information on the TCR speci...

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Publié dans:Nat Med
Auteurs principaux: Satpathy, Ansuman T., Saligrama, Naresha, Buenrostro, Jason D., Wei, Yuning, Wu, Beijing, Rubin, Adam J., Granja, Jeffrey M., Lareau, Caleb A., Li, Rui, Qi, Yanyan, Parker, Kevin R., Mumbach, Maxwell R., Serratelli, William S., Gennert, David G., Schep, Alicia N., Corces, M. Ryan, Khodadoust, Michael S., Kim, Youn H., Khavari, Paul A., Greenleaf, William J., Davis, Mark M., Chang, Howard Y.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948148/
https://ncbi.nlm.nih.gov/pubmed/29686426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0008-8
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