Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

Dysfunction in T cells limits the efficacy of cancer immunotherapy. We profiled the epigenome, transcriptome, and enhancer connectome of exhaustion-prone GD2-targeting HA-28z chimeric antigen receptor (CAR) T cells and control CD19-targeting CAR T cells, which present less exhaustion-inducing tonic...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Gennert, David G., Lynn, Rachel C., Granja, Jeff M., Weber, Evan W., Mumbach, Maxwell R., Zhao, Yang, Duren, Zhana, Sotillo, Elena, Greenleaf, William J., Wong, Wing H., Satpathy, Ansuman T., Mackall, Crystal L., Chang, Howard Y.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325267/
https://ncbi.nlm.nih.gov/pubmed/34285077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104758118
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