Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

Dysfunction in T cells limits the efficacy of cancer immunotherapy. We profiled the epigenome, transcriptome, and enhancer connectome of exhaustion-prone GD2-targeting HA-28z chimeric antigen receptor (CAR) T cells and control CD19-targeting CAR T cells, which present less exhaustion-inducing tonic...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Gennert, David G., Lynn, Rachel C., Granja, Jeff M., Weber, Evan W., Mumbach, Maxwell R., Zhao, Yang, Duren, Zhana, Sotillo, Elena, Greenleaf, William J., Wong, Wing H., Satpathy, Ansuman T., Mackall, Crystal L., Chang, Howard Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325267/
https://ncbi.nlm.nih.gov/pubmed/34285077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104758118
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