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Pharmacologic control of CAR-T cell function using dasatinib
Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity, cytokine secretion, and proliferation. Dasatinib could be repurposed as a safety switch to mitigate CAR-mediated toxicity in patients.
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| Gepubliceerd in: | Blood Adv |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society of Hematology
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6418502/ https://ncbi.nlm.nih.gov/pubmed/30814055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018028720 |
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