Transient “rest” restores functionality in exhausted CAR-T cells via epigenetic remodeling

T cell exhaustion limits immune responses against cancer and is a major cause of resistance to chimeric antigen receptor (CAR) T cell therapeutics. Using xenograft models and an in vitro model wherein tonic CAR signaling induces hallmark features of exhaustion, we tested the impact of transient cess...

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Publicado no:Science
Main Authors: Weber, Evan W., Parker, Kevin R., Sotillo, Elena, Lynn, Rachel C., Anbunathan, Hima, Lattin, John, Good, Zinaida, Belk, Julia A., Daniel, Bence, Klysz, Dorota, Malipatlolla, Meena, Xu, Peng, Bashti, Malek, Heitzeneder, Sabine, Labanieh, Louai, Vandris, Panayiotis, Majzner, Robbie G., Qi, Yanyan, Sandor, Katalin, Chen, Ling-Chun, Prabhu, Snehit, Gentles, Andrew J., Wandless, Thomas J., Satpathy, Ansuman T., Chang, Howard Y., Mackall, Crystal L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049103/
https://ncbi.nlm.nih.gov/pubmed/33795428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aba1786
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