Transient “rest” restores functionality in exhausted CAR-T cells via epigenetic remodeling

T cell exhaustion limits immune responses against cancer and is a major cause of resistance to chimeric antigen receptor (CAR) T cell therapeutics. Using xenograft models and an in vitro model wherein tonic CAR signaling induces hallmark features of exhaustion, we tested the impact of transient cess...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Science
Päätekijät: Weber, Evan W., Parker, Kevin R., Sotillo, Elena, Lynn, Rachel C., Anbunathan, Hima, Lattin, John, Good, Zinaida, Belk, Julia A., Daniel, Bence, Klysz, Dorota, Malipatlolla, Meena, Xu, Peng, Bashti, Malek, Heitzeneder, Sabine, Labanieh, Louai, Vandris, Panayiotis, Majzner, Robbie G., Qi, Yanyan, Sandor, Katalin, Chen, Ling-Chun, Prabhu, Snehit, Gentles, Andrew J., Wandless, Thomas J., Satpathy, Ansuman T., Chang, Howard Y., Mackall, Crystal L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049103/
https://ncbi.nlm.nih.gov/pubmed/33795428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aba1786
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia