Transient “rest” restores functionality in exhausted CAR-T cells via epigenetic remodeling

T cell exhaustion limits immune responses against cancer and is a major cause of resistance to chimeric antigen receptor (CAR) T cell therapeutics. Using xenograft models and an in vitro model wherein tonic CAR signaling induces hallmark features of exhaustion, we tested the impact of transient cess...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Weber, Evan W., Parker, Kevin R., Sotillo, Elena, Lynn, Rachel C., Anbunathan, Hima, Lattin, John, Good, Zinaida, Belk, Julia A., Daniel, Bence, Klysz, Dorota, Malipatlolla, Meena, Xu, Peng, Bashti, Malek, Heitzeneder, Sabine, Labanieh, Louai, Vandris, Panayiotis, Majzner, Robbie G., Qi, Yanyan, Sandor, Katalin, Chen, Ling-Chun, Prabhu, Snehit, Gentles, Andrew J., Wandless, Thomas J., Satpathy, Ansuman T., Chang, Howard Y., Mackall, Crystal L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049103/
https://ncbi.nlm.nih.gov/pubmed/33795428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aba1786
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg