The chromatin accessibility landscape of primary human cancers

We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from The Cancer Genome Atlas. We identify 562,709 transposase-accessible DNA elements that substantially extend the compendium of known cis-regulatory elements. Integration of ATAC-seq with TCGA...

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Publicado no:Science
Main Authors: Corces, M. Ryan, Granja, Jeffrey M., Shams, Shadi, Louie, Bryan H., Seoane, Jose A., Zhou, Wanding, Silva, Tiago C., Groeneveld, Clarice, Wong, Christopher K., Cho, Seung Woo, Satpathy, Ansuman T., Mumbach, Maxwell R., Hoadley, Katherine A., Robertson, A. Gordon, Sheffield, Nathan C., Felau, Ina, Castro, Mauro A.A., Berman, Benjamin P., Staudt, Louis M., Zenklusen, Jean C., Laird, Peter W., Curtis, Christina, Greenleaf, William J., Chang, Howard Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408149/
https://ncbi.nlm.nih.gov/pubmed/30361341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav1898
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