Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes

Despite the strong association between diabetes and dementia, it remains to be fully elucidated how insulin deficiency adversely affects brain functions. We show that insulin deficiency in streptozotocin-induced diabetic mice decreased mitochondrial ATP production and/or citrate synthase and cytochr...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Ruegsegger, Gregory N., Manjunatha, Shankarappa, Summer, Priska, Gopala, Srinivas, Zabeilski, Piotr, Dasari, Surendra, Vanderboom, Patrick M., Lanza, Ian R., Klaus, Katherine A., Nair, K. Sreekumaran
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404590/
https://ncbi.nlm.nih.gov/pubmed/30676773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802043R
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