Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes

Despite the strong association between diabetes and dementia, it remains to be fully elucidated how insulin deficiency adversely affects brain functions. We show that insulin deficiency in streptozotocin-induced diabetic mice decreased mitochondrial ATP production and/or citrate synthase and cytochr...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Ruegsegger, Gregory N., Manjunatha, Shankarappa, Summer, Priska, Gopala, Srinivas, Zabeilski, Piotr, Dasari, Surendra, Vanderboom, Patrick M., Lanza, Ian R., Klaus, Katherine A., Nair, K. Sreekumaran
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404590/
https://ncbi.nlm.nih.gov/pubmed/30676773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802043R
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