Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice

Insulin deprivation in type 1 diabetes (T1D) individuals increases lipolysis and plasma free fatty acids (FFA) concentration, which can stimulate synthesis of intramyocellular bioactive lipids such as ceramides (Cer) and long-chain fatty acid-CoAs (LCFa-CoAs). Ceramide was shown to decrease muscle i...

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Detalhes bibliográficos
Principais autores: Zabielski, Piotr, Blachnio-Zabielska, Agnieszka, Lanza, Ian R., Gopala, Srinivas, Manjunatha, S., Jakaitis, Daniel R., Persson, Xuan-Mai, Gransee, Jaime, Klaus, Katherine A., Schimke, Jill M., Jensen, Michael D., Nair, K. Sreekumaran
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948970/
https://ncbi.nlm.nih.gov/pubmed/24368672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00610.2012
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