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Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide

Data from animal experiments strongly suggest that ceramide is an important mediator of lipotoxicity in the heart and that accumulation of ceramide contributes to cardiomyocyte apoptosis associated with type 2 diabetes and obesity. However, it remains unknown whether a similar relationship is presen...

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Detalhes bibliográficos
Main Authors: Baranowski, Marcin, Blachnio-Zabielska, Agnieszka, Hirnle, Tomasz, Harasiuk, Dorota, Matlak, Krzysztof, Knapp, Malgorzata, Zabielski, Piotr, Gorski, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789788/
https://ncbi.nlm.nih.gov/pubmed/19617631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900002-JLR200
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