TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle

Diet-induced insulin resistance (IR) adversely affects human health and life span. We show that muscle-specific overexpression of human mitochondrial transcription factor A (TFAM) attenuates high-fat diet (HFD)–induced fat gain and IR in mice in conjunction with increased energy expenditure and redu...

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Bibliographic Details
Published in:Diabetes
Main Authors: Koh, Jin-Ho, Johnson, Matthew L., Dasari, Surendra, LeBrasseur, Nathan K., Vuckovic, Ivan, Henderson, Gregory C., Cooper, Shawna A., Manjunatha, Shankarappa, Ruegsegger, Gregory N., Shulman, Gerald I., Lanza, Ian R., Nair, K. Sreekumaran
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2019
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692815/
https://ncbi.nlm.nih.gov/pubmed/31088855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0088
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