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Metabolically Stabilized Double Stranded mRNA Polyplexes
The metabolic instability of mRNA currently limits its utility for gene therapy. Compared to plasmid DNA, mRNA is significantly more susceptible to digestion by RNase in the circulation following systemic dosing. To increase mRNA metabolic stability, we hybridized a complementary reverse mRNA with f...
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| Publicado en: | Gene Ther |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6404535/ https://ncbi.nlm.nih.gov/pubmed/30154525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-018-0038-3 |
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