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Efficient Expression of Stabilized mRNAPEG-Peptide Polyplexes in Liver
The expression efficiency in liver following hydrodynamic delivery of in vitro transcribed mRNA was improved 2000-fold using a codon-optimized mRNA luciferase construct with flanking 3' and 5' human β-globin untranslated regions (UTR mRNA) over an un-optimized mRNA without β-globin UTRs. N...
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| Gepubliceerd in: | Gene Ther |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4670273/ https://ncbi.nlm.nih.gov/pubmed/26125604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.68 |
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