Metabolically Stabilized Double Stranded mRNA Polyplexes

The metabolic instability of mRNA currently limits its utility for gene therapy. Compared to plasmid DNA, mRNA is significantly more susceptible to digestion by RNase in the circulation following systemic dosing. To increase mRNA metabolic stability, we hybridized a complementary reverse mRNA with f...

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Detaylı Bibliyografya
Yayımlandı:Gene Ther
Asıl Yazarlar: Poliskey, Jacob A., Crowley, Samuel T., Ramanathan, Raghu, White, Christopher W., Mathew, Basil, Rice, Kevin G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404535/
https://ncbi.nlm.nih.gov/pubmed/30154525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-018-0038-3
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