Targeted mRNA degradation by double-stranded RNA in vitro

Double-stranded RNA (dsRNA) directs gene-specific, post-transcriptional silencing in many organisms, including vertebrates, and has provided a new tool for studying gene function. The biochemical mechanisms underlying this dsRNA interference (RNAi) are unknown. Here we report the development of a ce...

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Autores principales: Tuschl, Thomas, Zamore, Phillip D., Lehmann, Ruth, Bartel, David P., Sharp, Phillip A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1999
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC317199/
https://ncbi.nlm.nih.gov/pubmed/10617568
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