Targeted mRNA degradation by double-stranded RNA in vitro

Double-stranded RNA (dsRNA) directs gene-specific, post-transcriptional silencing in many organisms, including vertebrates, and has provided a new tool for studying gene function. The biochemical mechanisms underlying this dsRNA interference (RNAi) are unknown. Here we report the development of a ce...

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Détails bibliographiques

Publié dans:	Genes Dev
Auteurs principaux:	Tuschl, Thomas, Zamore, Phillip D., Lehmann, Ruth, Bartel, David P., Sharp, Phillip A.
Format:	Artigo
Langue:	Inglês
Publié:	Cold Spring Harbor Laboratory Press 1999
Sujets:	Research Paper
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317199/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10617568/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.24.3191
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