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Targeted mRNA degradation by double-stranded RNA in vitro

Double-stranded RNA (dsRNA) directs gene-specific, post-transcriptional silencing in many organisms, including vertebrates, and has provided a new tool for studying gene function. The biochemical mechanisms underlying this dsRNA interference (RNAi) are unknown. Here we report the development of a ce...

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Published in:Genes Dev
Main Authors: Tuschl, Thomas, Zamore, Phillip D., Lehmann, Ruth, Bartel, David P., Sharp, Phillip A.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1999
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Research Paper
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317199/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10617568/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.24.3191
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