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Dynamic Stacking of an Expected Branch Point Adenosine in Duplexes containing Pseudouridine-Modified or Unmodified U2 snRNA Sites
The pre-mRNA branch point sequence (BPS) anneals with a pseudouridine-modified region of the U2 small nuclear (sn)RNA, and offers a 2′ hydroxyl group of a bulged adenosine as the nucleophile for the first catalytic step of pre-mRNA splicing. To increase our structural understanding of branch site se...
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| Publicado en: | Biochem Biophys Res Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6402984/ https://ncbi.nlm.nih.gov/pubmed/30797552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.02.073 |
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