Dynamic Stacking of an Expected Branch Point Adenosine in Duplexes containing Pseudouridine-Modified or Unmodified U2 snRNA Sites

The pre-mRNA branch point sequence (BPS) anneals with a pseudouridine-modified region of the U2 small nuclear (sn)RNA, and offers a 2′ hydroxyl group of a bulged adenosine as the nucleophile for the first catalytic step of pre-mRNA splicing. To increase our structural understanding of branch site se...

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Bibliographic Details
Published in:Biochem Biophys Res Commun
Main Authors: Kennedy, Scott D., Bauer, William J., Wang, Wenhua, Kielkopf, Clara L.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402984/
https://ncbi.nlm.nih.gov/pubmed/30797552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.02.073
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