Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3′ untranslated regions, targeting these mRNAs for rapid degradation. HuR contains three RNA recognition motifs (RRMs): a t...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Ripin, Nina, Boudet, Julien, Duszczyk, Malgorzata M., Hinniger, Alexandra, Faller, Michael, Krepl, Miroslav, Gadi, Abhilash, Schneider, Robert J., Šponer, Jiří, Meisner-Kober, Nicole C., Allain, Frédéric H.-T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386705/
https://ncbi.nlm.nih.gov/pubmed/30718402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808696116
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