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The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of Cyclooxygenase-2
Commonly observed in colorectal cancer (CRC) is elevated expression of the prostaglandin synthase cyclooxygenase-2 (COX-2). In normal intestinal epithelium, the COX-2 mRNA is targeted for rapid decay through the 3′-untranslated region (3′UTR) adenylate- and uridylate (AU)-rich element (ARE), whereas...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262080/ https://ncbi.nlm.nih.gov/pubmed/22049153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0337 |
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