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The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of Cyclooxygenase-2

Commonly observed in colorectal cancer (CRC) is elevated expression of the prostaglandin synthase cyclooxygenase-2 (COX-2). In normal intestinal epithelium, the COX-2 mRNA is targeted for rapid decay through the 3′-untranslated region (3′UTR) adenylate- and uridylate (AU)-rich element (ARE), whereas...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Young, Lisa E., Moore, Ashleigh E., Sokol, Lena, Meisner-Kober, Nicole, Dixon, Dan A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262080/
https://ncbi.nlm.nih.gov/pubmed/22049153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0337
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