Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

Cyclooxygenase-2 (COX-2) expression is normally tightly regulated. However, constitutive overexpression plays a key role in colon carcinogenesis. To understand the molecular nature of enhanced COX-2 expression detected in colon cancer, we examined the ability of the AU-rich element–containing (ARE-c...

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Main Authors: Dixon, Dan A., Tolley, Neal D., King, Peter H., Nabors, L. Burt, McIntyre, Thomas M., Zimmerman, Guy A., Prescott, Stephen M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC200983/
https://ncbi.nlm.nih.gov/pubmed/11733561
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