Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition

The Fox-1 RNA recognition motif (RRM) domain is an important member of the RRM protein family. We report a 1.8 Å X-ray structure of the free Fox-1 containing six distinct monomers. We use this and the nuclear magnetic resonance (NMR) structure of the Fox-1 protein/RNA complex for molecular dynamics...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Krepl, Miroslav, Blatter, Markus, Cléry, Antoine, Damberger, Fred F., Allain, Frédéric H.T., Sponer, Jiri
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737849/
https://ncbi.nlm.nih.gov/pubmed/28505313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx418
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