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Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation

Regulation of SMN2 exon 7 splicing is crucial for the production of active SMN protein and the survival of Spinal Muscular Atrophy (SMA) patients. One of the most efficient activators of exon 7 inclusion is hnRNP G, which is recruited to the exon by Tra2-β1. We report that in addition to the C-termi...

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Detalhes bibliográficos
Main Authors: Moursy, Ahmed, Allain, Frédéric H.-T., Cléry, Antoine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041419/
https://ncbi.nlm.nih.gov/pubmed/24692659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku244
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