hnRNP U Enhances Caspase-9 Splicing and Is Modulated by AKT-dependent Phosphorylation of hnRNP L

Caspase-9 has two splice variants, pro-apoptotic caspase-9a and anti-apoptotic caspase-9b, which are regulated by RNA trans-factors associated with exon 3 of caspase-9 pre-mRNA (C9/E3). In this study, we identified hnRNP U as an RNA trans-factor associated with C9/E3. Down-regulation of hnRNP U led...

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Detalhes bibliográficos
Main Authors: Vu, Ngoc T., Park, Margaret A., Shultz, Jacqueline C., Goehe, Rachel W., Hoeferlin, L. Alexis, Shultz, Michael D., Smith, Sarah A., Lynch, Kristen W., Chalfant, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605676/
https://ncbi.nlm.nih.gov/pubmed/23396972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443333
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