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Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination
The cyclooxygenase-2 is a pro-inflammatory and cancer marker, whose mRNA stability and translation is regulated by the CUG-binding protein 2 interacting with AU-rich sequences in the 3′ untranslated region. Here, we present the solution NMR structure of CUG-binding protein 2 RRM3 in complex with 5′-...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5608764/ https://ncbi.nlm.nih.gov/pubmed/28935965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00631-3 |
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