Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing

The human prototypical SR protein SRSF1 is an oncoprotein that contains two RRMs and plays a pivotal role in RNA metabolism. We determined the structure of the RRM1 bound to RNA and found that the domain binds preferentially to a CN motif (N is for any nucleotide). Based on this solution structure,...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cléry, Antoine, Krepl, Miroslav, Nguyen, Cristina K. X., Moursy, Ahmed, Jorjani, Hadi, Katsantoni, Maria, Okoniewski, Michal, Mittal, Nitish, Zavolan, Mihaela, Sponer, Jiri, Allain, Frédéric H.-T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813835/
https://ncbi.nlm.nih.gov/pubmed/33462199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20481-w
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