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HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of full-length HuR remain poorly understood. Here, w...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Pabis, Marta, Popowicz, Grzegorz M, Stehle, Ralf, Fernández-Ramos, David, Asami, Sam, Warner, Lisa, García-Mauriño, Sofía M, Schlundt, Andreas, Martínez-Chantar, María L, Díaz-Moreno, Irene, Sattler, Michael
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344896/
https://ncbi.nlm.nih.gov/pubmed/30418581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1138
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