HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of full-length HuR remain poorly understood. Here, w...

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Gardado en:
Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Pabis, Marta, Popowicz, Grzegorz M, Stehle, Ralf, Fernández-Ramos, David, Asami, Sam, Warner, Lisa, García-Mauriño, Sofía M, Schlundt, Andreas, Martínez-Chantar, María L, Díaz-Moreno, Irene, Sattler, Michael
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344896/
https://ncbi.nlm.nih.gov/pubmed/30418581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1138
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