HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of full-length HuR remain poorly understood. Here, w...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Pabis, Marta, Popowicz, Grzegorz M, Stehle, Ralf, Fernández-Ramos, David, Asami, Sam, Warner, Lisa, García-Mauriño, Sofía M, Schlundt, Andreas, Martínez-Chantar, María L, Díaz-Moreno, Irene, Sattler, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344896/
https://ncbi.nlm.nih.gov/pubmed/30418581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1138
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