Genetic inhibition of RIPK1 reduces cell death and improves functional outcome after intracerebral hemorrhage in mice

BACKGROUND AND PURPOSE: Recent studies using cultured cells and rodent intracerebral hemorrhage (ICH) models have implicated receptor interacting protein kinase-1 (RIPK1) as a driver of programmed necrosis and secondary injury based on use of chemical inhibitors. However, these inhibitors have off t...

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Detalhes bibliográficos
Publicado no:Stroke
Main Authors: Lule, Sevda, Wu, Limin, McAllister, Lauren M., Edmiston, William J., Chung, Joon Yong, Levy, Emily, Zheng, Yi, Gough, Peter J., Bertin, John, Degterev, Alexei, Lo, Eng H., Whalen, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366458/
https://ncbi.nlm.nih.gov/pubmed/28765287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.117.017702
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