RIPK1 and RIPK3 kinases promote cell death-independent inflammation by Toll-like receptor 4

Macrophages are a crucial component of the innate immune system in sensing pathogens and promoting local and systemic inflammation. RIPK1 and RIPK3 are homologous kinases, previously linked to activation of necroptotic death. In this study we have described roles for these kinases as master regulato...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos, Gough, Peter J., Bertin, John, Whalen, Michael, Pasparakis, Manolis, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander, Degterev, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956514/
https://ncbi.nlm.nih.gov/pubmed/27396959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.06.007
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