Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is recruited to the TNF receptor 1 to mediate proinflammatory signaling and to regulate TNF-induced cell death. RIPK1 deficiency results in postnatal lethality, but precisely why Ripk1(−/−) mice die remains unclear. To identify the linea...

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Detalles Bibliográficos
Main Authors: Roderick, Justine E., Hermance, Nicole, Zelic, Matija, Simmons, Matthew J., Polykratis, Apostolos, Pasparakis, Manolis, Kelliher, Michelle A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209989/
https://ncbi.nlm.nih.gov/pubmed/25246544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409389111
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