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RIPK1 kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo
The serine/threonine kinase RIPK1 is recruited to the TNF receptor 1 to mediate pro-inflammatory signalling and to regulate TNF-induced cell death. A RIPK1 deficiency results in perinatal lethality, impaired NFκB and MAPK signalling and sensitivity to TNF-induced apoptosis. Chemical inhibitor and in...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119562/ https://ncbi.nlm.nih.gov/pubmed/25015821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400590 |
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