RIPK1 kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

The serine/threonine kinase RIPK1 is recruited to the TNF receptor 1 to mediate pro-inflammatory signalling and to regulate TNF-induced cell death. A RIPK1 deficiency results in perinatal lethality, impaired NFκB and MAPK signalling and sensitivity to TNF-induced apoptosis. Chemical inhibitor and in...

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Hlavní autoři: Polykratis, Apostolos, Hermance, Nicole, Zelic, Matija, Roderick, Justine, Kim, Chun, Van, Trieu-My, Lee, Thomas H., Chan, Francis K.M., Pasparakis, Manolis, Kelliher, Michelle A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119562/
https://ncbi.nlm.nih.gov/pubmed/25015821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400590
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