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RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammation via kinase-dependent and -independent functions1–7. RIPK1 kinase activity induces caspase-8-dependent apoptosis and RIPK3/Mixed Lineage Kinase Like (MLKL)-dependent necroptosis8–13. In addition, RIPK1 inhibits apopto...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5755685/ https://ncbi.nlm.nih.gov/pubmed/27819681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20558 |
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