RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammation via kinase-dependent and -independent functions1–7. RIPK1 kinase activity induces caspase-8-dependent apoptosis and RIPK3/Mixed Lineage Kinase Like (MLKL)-dependent necroptosis8–13. In addition, RIPK1 inhibits apopto...

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Udgivet i:Nature
Main Authors: Lin, Juan, Kumari, Snehlata, Kim, Chun, Van, Trieu-My, Wachsmuth, Laurens, Polykratis, Apostolos, Pasparakis, Manolis
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755685/
https://ncbi.nlm.nih.gov/pubmed/27819681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20558
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