Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation

Z-DNA and Z-RNA are left-handed double helix nucleic acid structures with poorly understood biological function(1–3). Z-DNA binding protein 1 (ZBP1, also known as DAI or DLM-1) is a nucleic acid sensor containing two Zα domains that bind Z-DNA(4,5) and Z-RNA(6–8). ZBP1 mediates host-defence against...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Jiao, Huipeng, Wachsmuth, Laurens, Kumari, Snehlata, Schwarzer, Robin, Lin, Juan, Eren, Remzi Onur, Fisher, Amanda, Lane, Rebecca, Young, George R., Kassiotis, George, Kaiser, William J., Pasparakis, Manolis
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279955/
https://ncbi.nlm.nih.gov/pubmed/32296175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2129-8
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