Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1. Consequently, loss of RIPK1 in keratinocytes induces ZBP1-dependent necroptosis and s...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Devos, Michael, Tanghe, Giel, Gilbert, Barbara, Dierick, Evelien, Verheirstraeten, Maud, Nemegeer, Josephine, de Reuver, Richard, Lefebvre, Sylvie, De Munck, Jolien, Rehwinkel, Jan, Vandenabeele, Peter, Declercq, Wim, Maelfait, Jonathan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2020
Soggetti:
Brief Definitive Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336309/
https://ncbi.nlm.nih.gov/pubmed/32315377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191913
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